Immune status in preschool children born after mass hepatitis B vaccination program in Taiwan.
A mass hepatitis B vaccination program began in Taiwan in 1984.
In order to determine the immune status of hepatitis B virus (HBV) infection among preschool children, a total of 25 kindergartens in 20 townships and metropolitan precincts in central Taiwan were randomly selected through stratified sampling erum specimens of 2130 healthy preschool children aged 2-6 years old were screened for the HBV markers and liver function in 1996.
HBV surface antigen (HBsAg), antibody against HBsAg (anti-HBs) and antibody against HBV core antigen (anti-HBc) were tested by reverse passive hemagglutination (RPHA), enzyme immunoassay (EIA) and radioimmuno-assay (RIA) using commercial kits.
HBV vaccination rate of the preschool children was 98%, and complete vaccination rate (three or four doses of HBV vaccine) was 94%. The HBsAg seropositive rate was 4.5% among incomplete vaccinees and 1.3% among complete vaccinee The anti-HBs was detectable in 1637 of 2000 complete vaccinees (81.9%) and in 53 of 88 incomplete vaccinees (60.2%). The overall prevalence rate of anti-HBc was 2.4% (52 of 2130).
The older the age, the lower the anti-HBs seropositive rate, The anti-HBs seropositve rates for complete vaccinees were 100% at 2 years old and 75% at 6 years old.
There were no significant differences in HBsAg-seropositive rates and anti-HBs-seropositive rates among different residential areas or ethnic groups. (...)
Mots-clés Pascal : Virus hépatite B, Orthohepadnavirus, Hepadnaviridae, Virus, Hépatite virale B, Virose, Infection, Enfant, Homme, Etude longitudinale, Immunoprotection, Vaccination, Programme sanitaire, Campagne de masse, Taiwan, Asie, Gène kit
Mots-clés Pascal anglais : Hepatitis B virus, Orthohepadnavirus, Hepadnaviridae, Virus, Viral hepatitis B, Viral disease, Infection, Child, Human, Follow up study, Immunoprotection, Vaccination, Sanitary program, Mass campaign, Taiwan, Asia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0479780
Code Inist : 002B05A02. Création : 19/02/1999.