HPV 16 and cigarette smoking as risk factors for high-grade cervical intra-epithelial neoplasia.
Although genital human papillomavirus (HPV) infection is well established as the etiologic agent for cervical intra-epithelial neoplasia (CIN), little is known about the cofactors involved in the development of high-grade lesions or the progression of low-grade to high-grade lesions.
In our study of HPV-infected women with CIN (163 CIN 1,51 CIN II and 44 CIN III), women with CIN II or III were compared with those with CIN I for risk factors associated with high-grade lesions.
After controlling for age, education, ethnicity and frequency of Pap smear screening, infection with HPV 16, but not high viral load or infection with multiple types, was associated with high-grade lesions (OR for CIN II=11.96, OR for CIN III=23.74).
Risk of CIN III, but not CIN II, increased with number of cigarettes smoked per day (ORs=1.49 and 3.35 for <= 10 and>10 cigarettes per day, respectively) and decreased with frequency of condom use during sex (ORs=0.60 and 0.32 for women who used condoms occasionallylsometimes and most/all of the time, respectively).
There were no associations between high-grade lesions and plasma levels of micronutrients (retinol, bêta-carotene, alpha-tocopherol and reduced ascorbic acid).
Our results indicate that infection with HPV 16 is associated with high-grade lesions.
Additional cofactors, such as cigarette smoking, may be required as a carcinogen to advance HPV-infected cells toward neoplastic progression.
Mots-clés Pascal : Carcinome, Col utérus, Cancer in situ, Dysplasie, Haute malignité, Facteur risque, Epidémiologie, Tabagisme, Virose, Infection, Papillomavirus humain 16, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Micronutriment, Vitamine, Plasma sanguin, Condom, Relation sexuelle, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil génital femelle pathologie, Col utérus pathologie, Tumeur maligne, Lésion précancéreuse
Mots-clés Pascal anglais : Carcinoma, Uterine cervix, Carcinoma in situ, Dysplasia, High malignancy, Risk factor, Epidemiology, Tobacco smoking, Viral disease, Infection, Human papillomavirus 16, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Micronutrient, Vitamin, Blood plasma, Condom, Sexual intercourse, United States, North America, America, Human, Female genital diseases, Uterine cervix diseases, Malignant tumor, Premalignant lesion
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0479498
Code Inist : 002B20C02. Création : 19/02/1999.