From 1992 to 1994 a screening program for detection of specific Toxoplasma gondii antibodies involving 35,940 pregnant women was conducted in Norway.
For women with serological evidence of primary T. gondii infection, amniocentesis and antiparasitic treatment were offered.
The amniotic fluid was examined for T. gondii by PCR and mouse inoculation to detect fetal infection.
Infants of infected mothers had clinical and serological follow-up for at least 1 year to detect congenital infection.
Of the women 10.9% were infected before the onset of pregnancy.
Forty-seven women (0.17% among previously noninfected women) showed evidence of primary infection during pregnancy.
The highest incidence was detected (i) among foreign women (0.60%), (ii) in the capital city of Oslo (0.46%), and (iii) in the first trimester (0.29%). Congenital infection was detected in 11 infants, giving a transmission rate of 23% overall, 13% in the first trimester, 29% in the second, and 50% in the third.
During the 1-year follow-up period only one infant, born to an untreated mother, was found to be clinically affected (unilateral chorioretinitis and loss of vision).
At the beginning of pregnancy 0.6% of the previously uninfected women were falsely identified as positive by the Platelia Toxo-IgM test, the percentage increasing to 1.3% at the end of pregnancy.
Of the women infected prior to pregnancy 6.8% had persisting specific immunoglobulin M (IgM). (...)
Mots-clés Pascal : Toxoplasma gondii, Apicomplexa, Protozoa, Femelle, Nourrisson, Homme, Gestation, Epidémiologie, Prévalence, Diagnostic, IgM, Foetus pathologie, Transmission mère enfant, Etude longitudinale, Facteur risque, Toxoplasmose, Protozoose, Parasitose, Infection, Congénital, Maladie congénitale, Norvège, Europe, Pays Scandinaves
Mots-clés Pascal anglais : Toxoplasma gondii, Apicomplexa, Protozoa, Female, Infant, Human, Pregnancy, Epidemiology, Prevalence, Diagnosis, IgM, Fetal diseases, Mother to child transmission, Follow up study, Risk factor, Toxoplasmosis, Protozoal disease, Parasitosis, Infection, Congenital, Congenital disease, Norway, Europe, Scandinavia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0478785
Code Inist : 002B05E02B5. Création : 19/02/1999.