Gamma-glutamyl transferase (GGT), alanine transaminase (ALT), and aspartate transaminase (AST) are widely used as markers of hepatobiliary disorders in occupational health surveillance.
Little is known, however, about the prevalence and occupational and non-occupational determinants of elevated levels of these enzymes in specific occupational groups or about the prognostic value of elevated levels with respect to long-term outcomes such as all-cause mortality and vocational disability.
A cohort study was conducted among 8,043 male construction workers aged 25-64 years who had undergone occupational health examinations in 6 centers in southern Germany from 1986 to 1988 and had been followed until 1994.
The prevalence of elevated levels of GGT, ALT. and AST, depending on the sociodemographic and medical characteristics determined at the baseline examination and the risk of vocational disability and all-cause mortality in relation to elevated liver enzyme activity at baseline were assessed.
Covariates considered in multivariate analysis included age, nationality, occupation. body mass index (BMI), smoking, and alcohol consumption.
The baseline prevalence of elevated activity levels of GGT (>28 U/l at 25 °C), ALT (>22 U/l), and AST (>18 U/l) was 32%. 22%, and 12%, respectively.
Factors most strongly related to elevated serum activity levels for all three enzymes were self-reported alcohol consumption, diabetes, and hypertension. (...)
Mots-clés Pascal : Epidémiologie, Industrie construction, Homme, gamma-Glutamyltransferase, Aminoacyltransferases, Transferases, Enzyme, Alanine transaminase, Transaminases, Aspartate transaminase, Foie, Activité enzymatique, Mortalité, Incapacité travail, Retraite, Dépistage, Médecine travail, Facteur risque
Mots-clés Pascal anglais : Epidemiology, Construction industry, Human, gamma-Glutamyltransferase, Aminoacyltransferases, Transferases, Enzyme, Alanine transaminase, Transaminases, Aspartate transaminase, Liver, Enzymatic activity, Mortality, Work disability, Retirement, Medical screening, Occupational medicine, Risk factor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0476176
Code Inist : 002B30A01A2. Création : 19/02/1999.