Distribution of nickel in lungs from former nickel workers.
The purpose of this work was to study the distribution of nickel within lung tissue obtained from nickel-exposed people and to evaluate the use of only one single sample for determination of the nickel burden of the lung.
Methods and materials
The material used was lung tissue obtained from 15 former nickel refinery workers who had been exposed to a variety of nickel compounds such as Ni3S2, NiO, Ni0.
NiSO4, and NiCl2.
Ten samples taken from different locations of the lung as well as from the right and left bronchus and from the right lower lobe (total 13 samples per individual) were analyzed for nickel by electrothermal atomic absorption spectrometry.
Samples obtained from ten people not connected to the refinery served as a reference group.
The arithmetic mean value ± SD for nickel concentration was 50 ± 150 mug g-1 dry wt.
Biopsies collected on the center of the lower right lobe had an average nickel concentration of 82 ± 252 mug g-1.
The average nickel concentration detected in the right and left bronchus was 5.9 ± 11.6 and 3.8 ± 6.0 mug g-1. respectively.
Lung tissue obtained from ten people not connected to the refinery had an average nickel concentration of 0.74 ± 0.44 mug g-1. (...)
Mots-clés Pascal : Nickel, Métal lourd, Exposition professionnelle, Homme, Accumulation biologique, Poumon, Appareil respiratoire, Autopsie, Localisation, Distribution, Raffinerie, Mort, Médecine travail, Toxicocinétique
Mots-clés Pascal anglais : Nickel, Heavy metal, Occupational exposure, Human, Biological accumulation, Lung, Respiratory system, Autopsy, Localization, Distribution, Refinery, Death, Occupational medicine, Toxicokinetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0475552
Code Inist : 002B03L05. Création : 19/02/1999.