Objective and methods :
The exposure of Finnish tank lorry drivers to methyl tert-butyl ether (MTBE) and tert-amyl methyl ether (TAME) during loading of gasoline was studied using biological and breathing-zone sampling.
During the field measurements - in October 1994 and August 1995 the gasolines (95,98. 99 RON) contained MTBE to 5.2-11.8% and TAME to 0-6%, Results : The geometric mean (GM) breathing-zone concentration of MTBE was 4.3 mg/m3 (n=15) in October and 6.4 mg/m3 (n=20) in August.
The GM concentration of TAME, measured only in August, was 0.98 mg/m3, The mean loading/sampling times were 37 and 35 min, the mean wind speeds were 0.8 and 0.6 m/s, and the mean air temperatures were - 4.9° and+14.1 °C, respectively.
Blood samples collected on average at 20 min after gasoline loading/exposure showed an MTBE concentration of 143 nmol/l (GM, n=14) in October and 213 nmol/l (GM, n=20) in August.
Pearson's coefficient of correlation (r) between the MTBE breathing-zone concentrations and MTBE in blood was 0.86 (P=0.0001) in October and 0.81 (P=0.00001) in August.
No correlation was found between MTBE in air and the metabolite tert-butanol (TBA) in blood.
MTBE, but not TBA, in urine samples collected on average at 2.5 h after exposure showed a correlation with MTBE in air.
The concentrations of TAME and its metabolite tert-amyl alcohol were below the quantitation limits (<7 and<100 nmol/1, respectively) in most blood and urine samples. (...)
Mots-clés Pascal : Essence, Camion citerne, Remplissage, Exposition professionnelle, Conducteur véhicule, Homme, Surveillance biologique, Sang, Urine, Teneur air ambiant, Analyse quantitative, Liquide biologique, Médecine travail, Ether("t"-butyl méthyl), Ether("t"-amyl méthyl)
Mots-clés Pascal anglais : Gasoline, Tank truck, Filling, Occupational exposure, Vehicle driver, Human, Biological monitoring, Blood, Urine, Ambient air concentration, Quantitative analysis, Biological fluid, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0475498
Code Inist : 002B03L06. Création : 19/02/1999.