Parental smoking and spirometric indices in children.
Background-A systematic quantitative review was conducted of the evidence relating parental smoking to spirometric indices in children.
Methods-An electronic search of the Embase and Medline databases was completed in April 1997 and identified 692 articles from which we included four studies in neonates, 42 cross-sectional studies in school aged children (22 were included in a meta-analysis), and six longitudinal studies of lung function development.
In a pooled analyses of 21 surveys of school aged children the percentage reduction in forced expiratory volume in one second (FEV1) in children exposed to parental smoking compared with those not exposed was 1.4% (95% CI 1.0 to 1.9).
Effects were greater on mid expiratory flow rates (5.0% reduction, 95% CI 3.3 to 6.6) and end expiratory flow rates (4.3% reduction, 95% CI 3.1 to 5.5).
Adjustment for potential confounding variables had little effect on the estimates.
A number of studies reported clear evidence of exposure response.
Where exposure was explicitly identified it was usually maternal smoking.
Two studies in neonates have reported effects of prenatal exposure to maternal smoking.
Of five cross sectional studies that compared effects of perinatal exposure (retrospectively assessed) with current exposure to maternal smoking in later childhood, the three largest concluded that the major effect was in utero or neonatal exposure. (...)
Mots-clés Pascal : Tabagisme passif, Parent, Enfant, Homme, Tabagisme, Exploration, Fonction respiratoire, Spirométrie, Age scolaire, Toxicologie
Mots-clés Pascal anglais : Passive smoking, Parent, Child, Human, Tobacco smoking, Exploration, Lung function, Spirometry, School age, Toxicology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0471348
Code Inist : 002B03E. Création : 19/02/1999.