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  1. Role of follow-up in management of local recurrences of colorectal cancer : A prospective, randomized study.

    Article - En anglais


    This prospective, randomized, single-center study was designed to evaluate the influence of follow-up on detection and resectability of local recurrences and on survival after radical surgery for colorectal cancer.


    Between 1987 and 1990,207 consecutive patients who underwent curative resections for primary untreated large-bowel carcinoma were randomly assigned to a conventional follow-up group (Group A ; n=103) and to an intense follow-up group (Group B ; n=104).

    All the patients were followed up prospectively, and the outcome was known for all of them at five years.

    Patients in Group A were seen at six-month intervals for one year, and once a year thereafter.

    Patients in Group B were checked every three months during the first two years, at six-month intervals for the next three years, and once a year thereafter.


    Of the 103 patients in Group A, local recurrence was detected in 20 ; 9 (13 percent) of these patients had colon cancer, and 11 (29 percent) had rectal cancer.

    Of the 104 patients in Group B, local recurrence was detected in 26 ; 12 (16 percent) of these patients had colon cancer, and 14 (45 percent) had rectal cancer.

    Twelve cases (60 percent) of local recurrence in Group A and 24 cases (92 percent) in Group B were detected at scheduled visits (P<0.05).

    Local recurrences were detected earlier in patients of Group B (10.3 ± 2.7 vs. 20.2 ± 6.1 months ; P<0.0003). (...)

    Mots-clés Pascal : Carcinome, Côlon, Rectum, Récidive, Local, Etude longitudinale, Randomisation, Soin intégré, Pronostic, Chirurgie, Homme, Italie, Europe, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie

    Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Relapse, Premises, Follow up study, Randomization, Managed care, Prognosis, Surgery, Human, Italy, Europe, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0469755

    Code Inist : 002B25G02. Création : 19/02/1999.