The Overactive Bladder : from Basic Science to Clinical Management Consensus Conference. London, GBR, 1997/06/29.
Urge incontinence exacts a physical, psychological, and economic toll on affected individuals.
This article examines different approaches to estimate the burden of urge incontinence on patients and discusses how costs and consequences of treatments can be evaluated and compared to other interventions.
Willingness-to-pay methodology was used in Sweden to illustrate patients'distress.
Incontinence symptoms were compared to willingness-to-pay amounts and to health-related quality of life (QOL) as measured with a generic profile (SF-36) and a preference-based instrument (EuroQol).
These measures were also tested using data from a clinical trial in the United States.
A single effectiveness measure ( « normal days ») that would be meaningful to patients, physicians, and payers and could be used in cost-effectiveness analysis was tested in a multinational clinical trial.
Willingness to pay was significantly correlated with the expected health improvement, incontinence symptoms, and income.
SF-36 scores were significantly lower than for the general Swedish population and were correlated with the severity of symptoms.
Utility values obtained with EuroQo were also correlated with symptoms.
Similar results were obtained in the clinical trial.
The composite effectiveness measure was able to discriminate between treatment and placebo, despite a high placebo effect.
Mots-clés Pascal : Incontinence urinaire, Hyperactivité, Muscle detrusor, Vessie urinaire, Evaluation, Coût, Handicap physique, Traitement, Article synthèse, Homme, Appareil urinaire pathologie, Voie urinaire pathologie, Vessie pathologie, Trouble miction, Economie santé
Mots-clés Pascal anglais : Urinary incontinence, Hyperactivity, Detrusor muscle, Urinary bladder, Evaluation, Costs, Physical handicap, Treatment, Review, Human, Urinary system disease, Urinary tract disease, Bladder disease, Voiding dysfunction, Health economy
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0469310
Code Inist : 002B30A01C. Création : 19/02/1999.