The association between weight history and glucose intolerance was examined in a cross-sectional study consisting of 3,128 Swedish men aged 35-56 years, 52 percent of whom had a family background of diabetes mellitus.
Oral glucose tolerance testing detected 55 cases of type 2 (non-insulin-dependent) diabetes and 172 cases of impaired glucose tolerance.
Among men with no family history of diabetes, the estimated odds ratios for impaired glucose tolerance associated with short (<5 years) and long (=10 years) durations of obesity (body mass index (weight (kg)/height2 (m2) =25.0) were 1.3 (95% confidence interval (Cl) 0.2-7.7) and 11.8 (95% Cl 3.3-41.9), respectively.
Among men with a family history of diabetes, the odds ratios were 2.0 (95% Cl 0.8-4.7) and 4.0 (95% Cl 1.8-9.1), respectively.
Corresponding estimates of the odds of type 2 diabetes, adjusted for family history of diabetes, were 1.9 (95% Cl 0.5-7.1) and 7.3 (95% Cl 2.2-23.7), respectively.
The odds of high (=30.0 mU/liter) fasting insulin levels in subjects with impaired glucose tolerance were 6.9 (95% Cl 0.6-74.2) and 21.0 (95% Cl 2.1-206.4) for short and long durations of obesity, respectively.
Corresponding estimated odds of low 2-hour insulin response (<=71.9 mU/liter) were 0.7 (95% Cl 0.2-2.9) and 3.3 (95% Cl 1.2-8.9).
Homeostasis model assessment of insulin resistance yielded an odds ratio of 6.7 (95% Cl 0.6-73.4) for a short duration of obesity and 20.0 (95% Cl 2.0-200.6) for a long duration. (...)
Mots-clés Pascal : Obésité, Indice masse corporelle, Poids corporel, Diabète, Insuline, Taux, Plasma sanguin, Anomalie tolérance glucose, Epidémiologie, Facteur risque, Adulte, Homme, Mâle, Suède, Europe, Etat nutritionnel, Trouble nutrition, Endocrinopathie
Mots-clés Pascal anglais : Obesity, Body mass index, Body weight, Diabetes mellitus, Insulin, Rate, Blood plasma, Impaired glucose tolerance, Epidemiology, Risk factor, Adult, Human, Male, Sweden, Europe, Nutritional status, Nutrition disorder, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0468299
Code Inist : 002B21E01A. Création : 19/02/1999.