APMIS. ACTA PATHOLOGICA MICROBIOLOGICA ET IMMUNOLOGICA SCANDINAVICA, vol. 106, n° 6, 1998, pages 585-597, réf. 1p., ISSN 0903-4641, DNK
Department of Clinical Oncology and School of Public Health. University of Tampere. Helsinki. FIN, Department of Infectious Disease Epidemiology. National Public Health Institute. Helsinki. FIN
Comparative epidemiological studies have for a long time suggested a link (or links) between infectious agents and hematological malignancies in the young.
Identification of Epstein-Barr virus (EBV) as the major cause of specific subtypes of Burkitt's lymphoma and Hodgkin's disease 20 and 10 years ago, respectively, and the recent involvement of human T-cell leukemia virus in non-Hodgkin's lymphomas of the T-cell lineage in young adults in Jamaica have given further credit to early presumptions that these diseases have an infectious etiology.
The spectrum of possibly involved viruses : old, EBV, and new, herpesviruses 6,7 and 8, and unknown retroviruses - as well as the list of partially or totally unresolved disease entities : Hodgkin's disease in adolescents, non-Hodgkin's lymphomas in the immunocompromised, and acute lymphocytic leukemia - is rapidly expanding.
Both direct and indirect transforming effects of the above-mentioned viruses are being rapidly disclosed.
However, the complex interaction between the different viruses and other causes of hematological malignancies in the young guarantees that many things remain to be discovered also in the future.
Mots-clés BDSP : Lymphogranulomatose maligne, Etiologie, Virose, Infection, Virus, Rétrovirus, Epidémiologie, Etude comparée, Enfant, Homme, Adolescent
Mots-clés Pascal : Leucémie lymphoblastique, Hodgkin maladie, Lymphome non hodgkinien, Etiologie, Virose, Infection, Virus Epstein Barr, Gammaherpesvirinae, Herpesviridae, Virus, Herpesvirus hominis 6, Virus HTLV1, Retroviridae, Epidémiologie, Etude comparative, Article synthèse, Enfant, Homme, Adolescent, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome, Lymphome, Rhadinovirus, Herpesvirus hominis 8
Mots-clés Pascal anglais : Acute lymphocytic leukemia, Hodgkin disease, Non Hodgkin lymphoma, Etiology, Viral disease, Infection, Epstein Barr virus, Gammaherpesvirinae, Herpesviridae, Virus, Herpesvirus hominis 6, HTLV-I virus, Retroviridae, Epidemiology, Comparative study, Review, Child, Human, Adolescent, Acute, Malignant hemopathy, Lymphoproliferative syndrome, Lymphoma, Herpesvirus hominis 8
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