The Diet, Activity, and Reproduction in Colon Cancer (DARCC) study is a large, multi-center case-control study of colon cancer.
We examined family histories of cancer among first-degree relatives obtained by computer-assisted in-person interviews from the DARCC to study the impact of family histories of several cancers and colorectal polyps on colon cancer risk.
We examined familial cancer risks both by treating a family history of polyps or cancer as a covariate in a logistic regression model, and by comparing cancer or polyp incidence among relatives of cases to incidence among relatives of controls in a proportional hazards model.
There were few differences between the odds ratios (OR) or confidence intervals (Cl) generated from logistic regression models and the hazard rate ratios (HRR) generated from the proportional hazards models.
Overall, the OR of colon cancer among subjects with a family history of colorectal cancer was 1.77.
There were only minor differences in risk by sex, age and subsite.
A family history of colorectal polyps also increased risk by about the same amount as a family history of colorectal cancer.
The increased risk associated with a family history of polyps did not appear to decrease with age.
Mots-clés Pascal : Tumeur maligne, Côlon, Facteur risque, Polype, Rectum, Alimentation, Exercice physique, Reproduction, Antécédent, Histoire familiale, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Tumeur bénigne, Parenté premier degré
Mots-clés Pascal anglais : Malignant tumor, Colon, Risk factor, Polyp, Rectum, Feeding, Physical exercise, Reproduction, Antecedent, Family story, Epidemiology, United States, North America, America, Human, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Benign neoplasm, First degree relatives
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0464303
Code Inist : 002B13B01. Création : 19/02/1999.