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  1. Population based cohort study of the association between alcohol intake and cancer of the upper digestive tract. Commentary.

    Article - En anglais

    Objective 

    To examine the relation between different types of alcoholic drinks and upper digestive tract cancers (oropharyngeal and oesophageal).

    Design 

    Population based study with baseline assessment of intake of beer, wine, and spirits, smoking habits, educational level, and 2-19 years'follow up on risk of upper digestive tract cancer.

    Setting 

    Denmark.

    Subjects 

    15 117 men and 13 063 women aged 20 to 98 years.

    Main outcome measure 

    Number and time of identification of incident upper digestive tract cancer during follow up.

    Results 

    During a mean follow up of 13.5 years, 156 subjects developed upper digestive tract cancer.

    Compared with non-drinkers (drinkers of<1 drink/week), subjects who drank 7-21 beers or spirits a week but no wine were at a risk of 3.0 (95% confidence interval 1.5 to 6.1), whereas those who had the same total alcohol intake but with wine as =30% of their intake had a risk of 0.5 (0.2 to 1.4).

    Drinkers of>21 beers and spirits but no wine had a relative risk of 5.2 (2.7 to 10.2) compared with non-drinkers, whereas those who drank the same amount, but included wine in their alcohol intake, had a relative risk of 1.7 (0.6 to 4.4).

    Conclusion 

    A moderate intake of wine probably does not increase the risk of upper digestive tract cancer, whereas a moderate intake of beer or spirits increases the risk considerably.

    Mots-clés Pascal : Carcinome, Oesophage, Oropharynx, Boisson alcoolisée, Etude cohorte, Association, Facteur risque, Etude longitudinale, Homme, Danemark, Europe, Tumeur maligne, Appareil digestif pathologie, Oesophage pathologie, Toxicologie

    Mots-clés Pascal anglais : Carcinoma, Esophagus, Oropharynx, Alcoholic beverage, Cohort study, Association, Risk factor, Follow up study, Human, Denmark, Europe, Malignant tumor, Digestive diseases, Esophageal disease, Toxicology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0457613

    Code Inist : 002B13B01. Création : 25/01/1999.