Rectal epithelial proliferation (REP) measurements are used as a biomarker of risk for colorectal neoplasia and response to chemoprevention.
The authors evaluated REP in screenees with and without a history of adenoma and its association with demographic and adenoma characteristics, diet, and other lifestyle habits.
I. ong term lifestyle habits were evaluated and proliferation assessed by in vitro bromodeoxyuridine labeling of rectal biopsies in 223 screenees, 132 of whom had adenomas removed>3 years previously.
Analyses included the total population, screenees with a previous history of adenomas and adenoma free screenees separately, and a subgroup of 55 matched adenoma cases and controls.
Crypt proliferation measurements were not elevated in screenees with a history of adenomas compared with adenoma free screenees (mean total labeling index [LI] of 4.8% and 4.9%, respectively).
This was confirmed by the case-control analysis, in which the LI of the most superficial crypt compartment was lower in the adenoma cases (P=0.05).
Moreover. their total LI correlated negatively with the number of adenomas removed previously (P<0.01).
Proliferation was more frequent in the most superficial crypt compartments of female adenoma free screenees than in female screenees with a history of adenomas (P=0.02), and in men age>65 years compared with younger men (P=0.06). (...)
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Facteur risque, Multiplication cellulaire, Cellule épithéliale, Adénome, Alimentation, Mode de vie, Tabagisme, Antécédent, Histoire familiale, Etude cas témoin, Epidémiologie, Israël, Asie, Adulte, Homme, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Tumeur bénigne
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Risk factor, Cell proliferation, Epithelial cell, Adenoma, Feeding, Life habit, Tobacco smoking, Antecedent, Family story, Case control study, Epidemiology, Israel, Asia, Adult, Human, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Benign neoplasm
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0455865
Code Inist : 002B13B01. Création : 25/01/1999.