A population-based case-control study of renal cell cancer was conducted in Minnesota between 1988 and 1990.
It included 690 histologically confirmed incident cases identified through the state cancer surveillance system, and 707 age and sex frequency-matched controls.
In this paper, the authors present estimates of the proportion of renal cell cancer cases attributable (or population attributable risk (PAR)) to 1) well-established risk factors, namely smoking, excess weight, and hypertension, and 2) more speculative risk factors, namely elevated protein intake, history of renal disease (i.e., stone, injury, or infection) and high parity among women.
These estimates were based on information obtained from directly interviewed subjects (65% of cases and 100% of controls).
The PARs for the three main risk factors were 21% for hypertension (defined by a reported personal history of hypertension or of treatment with antihypertensive or diuretic drugs), 21% for excess weight (defined by an elevation of the usual body mass index above the first quartile), and 18% for smoking (past and current).
Overall, these three factors accounted for 49% of cases.
The proportion increased to 60% when the three more speculative risk factors were considered as well.
Sex-specific analyses revealed a greater impact of smoking among men mainly due to a higher prevalence of past smoking. (...)
Mots-clés Pascal : Tumeur maligne, Rein, Etude cas témoin, Facteur risque, Homme, Epidémiologie, Minnesota, Etats Unis, Amérique du Nord, Amérique, Appareil urinaire pathologie, Rein pathologie
Mots-clés Pascal anglais : Malignant tumor, Kidney, Case control study, Risk factor, Human, Epidemiology, Minnesota, United States, North America, America, Urinary system disease, Kidney disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0453696
Code Inist : 002B14D01. Création : 25/01/1999.