This article is a review of the evidence suggesting a unique relationship between the varicella-zoster virus (as a possible antigen or antigen mimic) and multiple sclerosis (MS).
Both MS and varicella have increased prevalences in temperate zones and both are rare in countries closer to the equator, Migration studies suggest an infectious agent acquired prior to age 14 plays a role in the risk of subsequent MS.
Hutterites, who educate their children at home, have less varicella, MS, and herpes zoster than their neighbors and have the appropriate reduced varicella-zoster seropositivity matching these clinical observations.
Paradoxically, patients with MS report more herpes zoster, and at an earlier age and more often, than a group of non-MS patients.
Mots-clés Pascal : Sclérose en plaque, Varicelle, Virose, Infection, Herpès, Epidémiologie, Facteur risque, Homme, Système nerveux pathologie, Système nerveux central pathologie, Maladie inflammatoire
Mots-clés Pascal anglais : Multiple sclerosis, Varicella, Viral disease, Infection, Herpes, Epidemiology, Risk factor, Human, Nervous system diseases, Central nervous system disease, Inflammatory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0453577
Code Inist : 002B05C02A. Création : 25/01/1999.