Study objective-To investigate and evaluate published data on cost effectiveness of cholesterol lowering interventions, and how this information could be interpreted in a rational approach of cholesterol management in general practice.
Setting-No restriction on setting.
Materials-Papers reporting on the cost effectiveness or cost utility of prevention of (recurrent) coronary heart disease by reduction of hypercholesterolaemia in adults.
Main results-Thirty nine studies, most cost effectiveness analyses, were included.
In 24 studies drug interventions only were analysed.
Costs of screening to target cholesterol lowering interventions to persons with hypercholesterolaemia were considered in nine studies.
Adjustments of the efficacy of the intervention for community effectiveness were described in seven studies.
In four studies life years gained were adjusted for quality of life.
Despite large variation in the outcomes, there is a constant tendency towards a less favourable cost effectiveness ratio for intervening in persons without coronary heart disease compared with persons with coronary heart disease and for women compared with men.
Conclusions-There is lack of data on cost effectiveness of cholesterol lowering interventions in the general practice setting. (...)
Mots-clés Pascal : Hypercholestérolémie, Epidémiologie, Chimiothérapie, Traitement, Analyse coût efficacité, Adulte, Homme, Economie santé, Lipide, Revue bibliographique, Métabolisme pathologie, Dyslipémie, Hyperlipoprotéinémie
Mots-clés Pascal anglais : Hypercholesterolemia, Epidemiology, Chemotherapy, Treatment, Cost efficiency analysis, Adult, Human, Health economy, Lipids, Bibliographic review, Metabolic diseases, Dyslipemia, Hyperlipoproteinemia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0452720
Code Inist : 002B22A. Création : 25/01/1999.