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  1. Comparison of three composite compliance indices in a trial of self-administered preventive therapy for tuberculosis in HIV-infected Ugandan adults.

    Article - En anglais

    Compliance with tuberculosis preventive therapy in a randomized placebo-controlled trial in 2736 HIV-infected Ugandans was measured using urinary isoniazid metabolite testing, clinic attendance, and self-report.

    Overall, 77% of urine tests were positive, subjects kept 85% of their scheduled visits while on therapy, and 69% reportedly never forgot to take their medication.

    Different strategies were used for constructing three composite compliance indices in active arms :

    • (1) an unweighted index of the summed scores on scaled compliance measures ;

    • (2) a weighted index using weights obtained from a survey of experts on tuberculosis ;

    • and (3) a statistically weighted index using principal components analysis.

    Composite indices were evaluated for reliability, validity, and practical utility.

    Understanding of the regimen, study arm, subsequent follow-up, tuberculosis status, and urine spot-check result were associated with composite compliance scores.

    The unweighted index in this study performed as well as the weighted indices.

    Mots-clés Pascal : Tuberculose, Mycobactériose, Bactériose, Infection, Isoniazide, Antituberculeux, SIDA, Virose, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Epidémiologie, Chimiothérapie, Traitement, Efficacité traitement, Homme, Essai thérapeutique contrôlé, Etude comparative, Prévention, Immunopathologie, Immunodéficit, Etats Unis, Amérique du Nord, Amérique

    Mots-clés Pascal anglais : Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Isoniazid, Antituberculous agent, AIDS, Viral disease, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Epidemiology, Chemotherapy, Treatment, Treatment efficiency, Human, Controlled therapeutic trial, Comparative study, Prevention, Immunopathology, Immune deficiency, United States, North America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0452340

    Code Inist : 002B05C02D. Création : 25/01/1999.