On the carcinogenic risk evaluation of diesel exhaust : Benzene in airborne particles and alterations of heme metabolism in lymphocytes as markers of exposure.
Diesel exhaust consists of a complex mixture of chemicals which contain known genotoxicants, one of which is benzene.
Therefore the concentration of benzene may be used in the evaluation of full external exposure to diesel exhaust.
Our attention is focused on the determination of the distribution of benzene between the gas and particulate phases in the breathing zone of bus-garage workers.
Bus diesel engine exhaust was the main source of air pollution by benzene and particles.
The particulate matter contained benzene in amounts comparable to those usually found for concentrations of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and nitro-PAHs.
A much lower concentration of benzene was associated with particulate matter in the winter than in the summer months.
The level of benzene in the gas phase showed a dependence on the distance of workplace from the operating diesel motor.
The study indicated that benzene associated with diesel exhaust particles (DEP) might be an important factor to consider when studying diesel exhaust exposure from air pollution sources.
Since non-genotoxic effects may play an important role in the generation of tumors by genotoxic carcinogens, the level of heme synthesis was proposed as a biomarker of early health effect.
Here we present the data on determination of 5-aminolevulinic acid (ALA) synthesis and heme formation in lymphocytes from a group of 45 bus-garage workers and an analogous data from a group of 25 unexposed subjects. (...)
Mots-clés Pascal : Moteur diesel, Gaz échappement, Toxicité, Carcinogène, Evaluation, Risque, Tumorigénicité, Benzène, Pollution air, Particule en suspension, Composé aromatique polycyclique, Surveillance biologique, Homme, Exposition professionnelle, Hème, Protoporphyrine, Marqueur biologique, Lymphocyte, Lévulinique acide(5-amino)
Mots-clés Pascal anglais : Diesel engine, Exhaust gas, Toxicity, Carcinogen, Evaluation, Risk, Tumorigenicity, Benzene, Air pollution, Suspended particle, Polycyclic aromatic compound, Biological monitoring, Human, Occupational exposure, Heme, Protoporphyrin, Biological marker, Lymphocyte
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0449413
Code Inist : 002B03M02. Création : 25/01/1999.