Clinical implications of nosocomial gram-positive bacteremia and superimposed antimicrobial resistance.
The spector of Glycopeptide Resistance : Current Trends and Future Considerations. Satellite symposium. Toronto, ON, CAN, 1997/09/27.
The coexistence of a pathogen population with an ever-increasing resistance to many antibiotics and a patient population characterized by increasingly complex clinical problems has contributed to an increase in the bloodstream infections associated with gram-positive bacteria.
This serious therapeutic challenge has already been associated with an increase in infection-related morbidity and mortality, a prolongation of hospital stays, and an escalation of healthcare costs.
Vancomycin resistance, long prevalent among the enterococci, has emerged in strains of Staphylococcus aureus.
Several cases of infection caused by S. aureus strains with intermediate-level resistance to vancomycin (MIC=8 mug/mL) have recently been reported.
As glycopeptide resistance accelerates among the gram-positive bacteria, so does the potential for adverse clinical consequences associated with bloodstream infections caused by these pathogens.
The patients least able to tolerate the effects of uncontrolled bloodstream infections are also those at the highest risk for the development of infections caused by glycopeptide-resistant pathogens.
In this at-risk population, a poor outcome may be anticipated if effective antibiotic therapy is unavailable. (...)
Mots-clés Pascal : Infection nosocomiale, Bactérie Gram positif, Pathogénie, Complication, Résistance traitement, Chimiothérapie, Antibactérien, Traitement, Article synthèse, Homme, Bactériose, Infection
Mots-clés Pascal anglais : Nosocomial infection, Gram positive bacteria, Pathogenesis, Complication, Negative therapeutic reaction, Chemotherapy, Antibacterial agent, Treatment, Review, Human, Bacteriosis, Infection
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0443677
Code Inist : 002B05B01. Création : 25/01/1999.