The emergence of Staphylococcus aureus with reduced susceptibility to vancomycin in Japan.
The spector of Glycopeptide Resistance : Current Trends and Future Considerations. Satellite symposium. Toronto, ON, CAN, 1997/09/27.
Within the past year, infections caused by methicillin-resistant Staphylococcus aureus (MRSA) strains with reduced susceptibility to vancomycin (MIC=8 mug/mL) have been reported in both Japan and the United States.
The emergence of these strains poses a potentially serious threat to public health.
After 2 such strains (Mu3 and Mu50) were identified at Juntendo Hospital in 1996, a screening program to identify MRSA strains with reduced susceptibility to vancomycin was initiated.
Of 970 MRSA strains tested at 195 nonuniversity hospitals throughout Japan, 13 (1.3%) were found to have subpopulations with reduced vancomycin susceptibility (heterogeneous vancomycin resistance).
Among 129 MRSA strains identified at 7 university hospitals, 12 (9.3%) demonstrated heterogeneity for vancomycin resistance ; 1 of these strains had a vancomycin MIC of 7 mug/mL.
Although resistance in these strains is not the result of the transfer of enterococcal vancomycin resistance genes (vanA or vanB), the clonal dissemination of MRSA strains with vancomycin-resistant subpopulations is obviously undesirable.
Intensified testing of MRSA strains for resistance to vancomycin and appropriate measures for the prevention of the spread of such strains are recommended.
Mots-clés Pascal : Bactériose, Infection, Staphylococcus aureus, Micrococcaceae, Micrococcales, Bactérie, Acquisition, Résistance traitement, Chimiothérapie, Antibactérien, Vancomycine, Glycopeptide, Epidémiologie, Homme, Japon, Asie, Polypeptide
Mots-clés Pascal anglais : Bacteriosis, Infection, Staphylococcus aureus, Micrococcaceae, Micrococcales, Bacteria, Acquisition, Negative therapeutic reaction, Chemotherapy, Antibacterial agent, Vancomycin, Glycopeptide, Epidemiology, Human, Japan, Asia, Polypeptide
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0443675
Code Inist : 002B02S02. Création : 25/01/1999.