Background Recent studies have found that cotinine is a better predictor of birthweight than the number of cigarettes smoked in pregnancy.
In this paper we test this hypothesis and use cotinine to explore the effect of environmental tobacco smoke (ETS) on birthweight.
Methods In all, 1254 white women were interviewed at booking, 28 and 36 weeks about the number and brand of cigarette smoked.
Cotinine was assayed from blood samples taken on the day of interview.
The outcome was birthweight for gestational age.
Results There was good agreement between self-reported smoker/non-smoker status and maternal cotinine with 1.3% women mis-reported as non-smokers at booking, 0.6% and 1.8% mis-reported at 28 and 36 weeks respectively.
Among smokers, cotinine was more closely related to birthweight than the number of cigarettes smoked at all three time points (r=-0.25 versus r=-0.16 at booking).
A reduction in cotinine between booking and 28 weeks was associated with increased birthweight but the effect was not statistically significant.
Among non-smokers the association between birthweight and cotinine was not statistically significant after adjusting for maternal height, parity, sex and gestational age.
Difference in mean birthweight between non-smokers in the lower and upper quintiles of cotinine was 0.2% (95% CI : - 2.4,2.8). (...)
Mots-clés Pascal : Nicotine, Plasma sanguin, Mère, Gestation, Tabagisme, Tabagisme passif, Poids naissance, Age gestation, Hypotrophie foetale, Epidémiologie, Facteur risque, Taux, Nouveau né, Homme, Femelle, Métaanalyse, Gestation pathologie, Foetus pathologie
Mots-clés Pascal anglais : Nicotine, Blood plasma, Mother, Pregnancy, Tobacco smoking, Passive smoking, Birth weight, Gestational age, Intrauterine growth retardation, Epidemiology, Risk factor, Rate, Newborn, Human, Female, Metaanalysis, Pregnancy disorders, Fetal diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0441733
Code Inist : 002B20F02. Création : 25/01/1999.