Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina.
Background Studies in Taiwan have found dose-response relations between arsenic ingestion from drinking water and cancers of the skin, bladder, lung, kidney and liver.
To investigate these associations in another population, we conducted a study in C6rdoba, Argentina, which has a well-documented history of arsenic exposure from drinking water.
Methods Mortality from lung, kidney, liver and skin cancers during the period 1986-1991 in Cordoba's 26 counties was investigated, expanding the authors'previous analysis of bladder cancer in the province.
Counties were grouped a priori into low, medium and high arsenic exposure categories based on available data.
Standardized mortality ratios (SMR) were calculated using all of Argentina as the reference population.
Results We found increasing trends for kidney and lung cancer mortality with arsenic exposure, with the following SMR, for men and women respectively : kidney cancer, 0.87,1.33,1.57 and 1.00,1.36,1.81 ; lung cancer, 0.92,1.54,1.77 and 1.24,1.34,2.16 (in all cases, P<0.001 in trend test), similar to the previously reported bladder cancer results (0.80,1.28,2.14 for men, 1.22,1.39,1.81 for women).
There was a small positive trend for liver cancer but mortality was increased in all three exposure groups.
Skin cancer mortality was elevated for women only in the high exposure group, while men showed a puzzling increase in mortality in the low exposure group. (...)
Mots-clés Pascal : Tumeur maligne, Poumon, Rein, Mortalité, Pollution eau, Exposition, Polluant, Arsenic, Eau alimentation, Epidémiologie, Facteur risque, Relation dose réponse, Homme, Argentine, Amérique du Sud, Amérique, Santé et environnement, Toxicité, Appareil respiratoire pathologie, Poumon pathologie, Rein pathologie, Appareil urinaire pathologie, Métal lourd
Mots-clés Pascal anglais : Malignant tumor, Lung, Kidney, Mortality, Water pollution, Exposure, Pollutant, Arsenic, Feed water, Epidemiology, Risk factor, Dose activity relation, Human, Argentina, South America, America, Health and environment, Toxicity, Respiratory disease, Lung disease, Kidney disease, Urinary system disease, Heavy metal
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0440731
Code Inist : 002B03M03. Création : 25/01/1999.