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  1. Regional serum cholesterol differences in Belgium : do genetically determined cardiovascular risk factors contribute ?

    Article - En anglais

    Background Differences in serum lipid distribution and mortality from ischaemic heart disease have repeatedly been reported between Belgian northerners and southerners.

    We investigated whether serum lipoprotein (a) (Lp (a)) and apolipoprotein (apo) E polymorphism were involved.

    Methods Fasting serum lipids, apo A-I and B, and Lp (a) levels were examined in randomly selected, 20-39 year old Belgian males and females from the north (Flanders) and the south (Wallonia) of Belgium (N=900).

    Apo E phenotype distribution was investigated in random subsamples from either region (N=249).

    Results Mean serum cholesterol, low density lipoprotein cholesterol (LDL-c), apo B and triglyceride levels were higher in Walloons compared to Flemings within each gender, the difference being significant in 30-39 year old males.

    Average high density lipoprotein cholesterol and apo A-I levels were significantly lower in 30-39 year old male southerners, compared to their northern counterparts, Median Lp (a) was 67 mg/l in northerners and 75 mg/l in southerners (NS).

    The apo E phenotype distribution was similar in both regions (x2=7.213 ; d.f.=5 ; P=0.2053), whereas the average effects of the apo E alleles differed between the regions.

    In southerners the epsilon4 effect upon adjusted apo B and LDL-c levels was+12% and the epsilon2 effect was - 15% ; in northerners the epsilon4 and epsilon2 effects were+5% and - 25%, respectively.

    The apo E polymorphism did not affect serum Lp (a) levels. (...)

    Mots-clés Pascal : Cholestérolémie, Lipide, Plasma sanguin, Apolipoprotéine, Appareil circulatoire pathologie, Génétique, Epidémiologie, Facteur risque, Prévalence, Adulte jeune, Homme, Répartition géographique, Etude comparative, Belgique, Europe, Métabolisme pathologie

    Mots-clés Pascal anglais : Cholesterolemia, Lipids, Blood plasma, Apolipoproteins, Cardiovascular disease, Genetics, Epidemiology, Risk factor, Prevalence, Young adult, Human, Geographic distribution, Comparative study, Belgium, Europe, Metabolic diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0440562

    Code Inist : 002B22D02. Création : 25/01/1999.