A positive relationship has generally been observed between plasma estrogen levels and breast cancer risk in postmenopausal women, but most of these studies have been small and few have evaluated specific estrogen fractions (such as percent bioavailable estradiol).
In addition, few studies have evaluated plasma androgen levels in relation to breast cancer risk, and their results have been inconsistent.
We prospectively evaluated relationships between sex steroid hormone levels in plasma and risk of breast cancer in postmenopausal women by use of a case-control study nested within the Nurses'Health Study.
Blood samples were collected during the period from 1989 through 1990.
Among postmenopausal women not using hormone replacement therapy at blood collection (n=11169 women), 156 women were diagnosed with breast cancer after blood collection but before June 1,1994.
Two control subjects were selected per case subject and matched with respect to age, menopausal status, month and time of day of blood collection, and fasting status at the time of blood collection.
From comparisons of highest and lowest (reference) quartiles, we observed statistically significant positive associations with risk of breast cancer for circulating levels of estradiol (multivariate relative risk [RR]=1.91 ; 95% confidence interval [CI]=1.06-3.46), estrone (multivariate RR=1.96 ; 95% CI=1.05-3.65), estrone sulfate (multivariate RR=2.25 ; 95% CI=1.23-4. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Postménopause, Facteur risque, Epidémiologie, Estradiol, Plasma sanguin, Estrone, Déhydroépiandrostérone sulfate, Etude cohorte, Etats Unis, Amérique du Nord, Amérique, Homme, Glande mammaire pathologie, Oestrogène, Hormone stéroïde sexuelle, Hormone ovarienne, Androgène
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Postmenopause, Risk factor, Epidemiology, Estradiol, Blood plasma, Estrone, Dehydroepiandrosterone sulfate, Cohort study, United States, North America, America, Human, Mammary gland diseases, Estrogen, Sex steroid hormone, Ovarian hormone, Androgen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0438830
Code Inist : 002B20E02. Création : 25/01/1999.