We studied the associations between c-erbB-2 protein overexpression and p53 protein accumulation in benign breast tissue and the risk of subsequent breast cancer.
We conducted a case-control study nested within the cohort of 4888 women in the National Breast Screening Study (NBSS) who were diagnosed with benign breast disease during active follow-up.
Case subjects were the women who subsequently developed breast cancer (ductal carcinoma in situ [DCIS] or invasive carcinoma).
Control subjects were matched to each case subject on NBSS study arm, screening center, year of birth, and age at diagnosis of benign breast disease.
Histologic sections of benign and cancerous breast tissues were analyzed immunohistochemically.
Information on potential confounding factors was obtained by use of a self-administered lifestyle questionnaire.
Accumulation of p53 protein was associated with an increased risk of progression to breast cancer (adjusted odds ratio [OR]=2.55 ; 95% confidence interval [CI]=1.01-6.40), whereas c-erbB-2 protein overexpression was not (adjusted OR=0.65 ; 95% Cl=0.27-1.53).
The findings for c-erbB-2 and p53 did not differ among strata defined by menopausal status, allocation within the NBSS, history of breast disease, and whether the benign breast disease was detected at a scheduled screen or between screens. (...)
Mots-clés Pascal : Carcinome, Glande mammaire, Facteur risque, Epidémiologie, Surexpression génique, Gène onc cellulaire, Protooncogène, Gène suppresseur tumeur, Gène TP53, Expression génique, Immunohistochimie, Etude cas témoin, Canada, Amérique du Nord, Amérique, Homme, Tumeur maligne, Glande mammaire pathologie, Anatomopathologie, Gène erbB2
Mots-clés Pascal anglais : Carcinoma, Mammary gland, Risk factor, Epidemiology, Gene overexpression, C-Onc gene, Protooncogene, Tumor suppressor gene, TP53 Gene, Gene expression, Immunohistochemistry, Case control study, Canada, North America, America, Human, Malignant tumor, Mammary gland diseases, Pathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0438826
Code Inist : 002B20E02. Création : 25/01/1999.