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  1. Urinary N-acetyl-bêta-glucosaminidase as an indicator of renal dysfunction in electroplating workers.

    Article - En anglais

    Objectives 

    To investigate chromium-induced renal dysfunction in electroplating workers.

    Methods 

    A cross-sectional study was used to evaluate four biochemical markers of renal function.

    A total of 178 workers were divided into 3 comparable groups consisting of 34 hard-chrome plating workers, 98 nickel-chrome electroplating workers. and 46 aluminum anode-oxidation workers, who represented the reference group.

    Ambient and biological monitoring of urinary chromium were performed to measure exposure concentrations.

    Results 

    Overall, urinary chromium concentrations were highest among hard-chrome plating workers (geometric mean 2.44 mug/g creatinine), followed by nickel-chrome electroplating workers (0.31 mug/g creatinine) and aluminum workers (0.09 mug/g creatinine).

    Airborne chromium concentrations were also highest in the hard-chrome plating area (geometric mean 4.20 mug/m3), followed by the nickel-chrome electroplating area (0.58 mug/m3) and the aluminum area (0.43 mug/m3).

    A positive correlation was found between urinary chromium and airborne concentrations (r=0.54, P<0.01).

    Urinary concentrations of N-acetyl-bêta-D-glucosaminidase (NAG) were also highest among hard-chrome plating workers (geometric mean 4.9 IU/g creatinine), followed by nickel-chrome workers (3.4 IU/g creatinine) and aluminum workers (2.9 IU/g creatinine).

    The prevalence of elevated'NAG (>7 IU/g creatinine) was significantly highest among hard-chrome plating workers (23. (...)

    Mots-clés Pascal : Chrome, Métal lourd, Toxicité, Rein, Appareil urinaire pathologie, Dépôt électrolytique, Exposition professionnelle, Médecine travail, Homme, Marqueur biologique, bêta-N-Acetylhexosaminidase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Surveillance biologique, Urine, Liquide biologique

    Mots-clés Pascal anglais : Chromium, Heavy metal, Toxicity, Kidney, Urinary system disease, Electrodeposition, Occupational exposure, Occupational medicine, Human, Biological marker, bêta-N-Acetylhexosaminidase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Biological monitoring, Urine, Biological fluid

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0437513

    Code Inist : 002B03L05. Création : 25/01/1999.