Urinary N-acetyl-bêta-glucosaminidase as an indicator of renal dysfunction in electroplating workers.
To investigate chromium-induced renal dysfunction in electroplating workers.
A cross-sectional study was used to evaluate four biochemical markers of renal function.
A total of 178 workers were divided into 3 comparable groups consisting of 34 hard-chrome plating workers, 98 nickel-chrome electroplating workers. and 46 aluminum anode-oxidation workers, who represented the reference group.
Ambient and biological monitoring of urinary chromium were performed to measure exposure concentrations.
Overall, urinary chromium concentrations were highest among hard-chrome plating workers (geometric mean 2.44 mug/g creatinine), followed by nickel-chrome electroplating workers (0.31 mug/g creatinine) and aluminum workers (0.09 mug/g creatinine).
Airborne chromium concentrations were also highest in the hard-chrome plating area (geometric mean 4.20 mug/m3), followed by the nickel-chrome electroplating area (0.58 mug/m3) and the aluminum area (0.43 mug/m3).
A positive correlation was found between urinary chromium and airborne concentrations (r=0.54, P<0.01).
Urinary concentrations of N-acetyl-bêta-D-glucosaminidase (NAG) were also highest among hard-chrome plating workers (geometric mean 4.9 IU/g creatinine), followed by nickel-chrome workers (3.4 IU/g creatinine) and aluminum workers (2.9 IU/g creatinine).
The prevalence of elevated'NAG (>7 IU/g creatinine) was significantly highest among hard-chrome plating workers (23. (...)
Mots-clés Pascal : Chrome, Métal lourd, Toxicité, Rein, Appareil urinaire pathologie, Dépôt électrolytique, Exposition professionnelle, Médecine travail, Homme, Marqueur biologique, bêta-N-Acetylhexosaminidase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Surveillance biologique, Urine, Liquide biologique
Mots-clés Pascal anglais : Chromium, Heavy metal, Toxicity, Kidney, Urinary system disease, Electrodeposition, Occupational exposure, Occupational medicine, Human, Biological marker, bêta-N-Acetylhexosaminidase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Biological monitoring, Urine, Biological fluid
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0437513
Code Inist : 002B03L05. Création : 25/01/1999.