Breath, urine, and blood measurements as biological exposure indices of short-term inhalation exposure to methanol.
Due to their transient nature, short-term exposures can be difficult to detect and quantify using conventional monitoring techniques.
Biological monitoring may be capable of registering such exposures and may also be used to estimate important toxicological parameters.
This paper investigates relationships between methanol concentrations in the blood, urine, and breath of volunteers exposed to methanol vapor at 800 ppm for periods of 0.5,1,2, and 8 h. The results indicate factors that must be considered for interpretation of the results of biological monitoring.
For methanol, concentrations are not proportional to the exposure duration due to metabolic and other elimination processes that occur concurrently with the exposure.
First-order clearance models can be used with blood, breath, or urine concentrations to estimate exposures if the time that has elapsed since the exposure and the model parameters are known.
The 0.5 to 2-h periods of exposure were used to estimate the half-life of methanol.
Blood data gave a half-life of 1.44 ± 0.33 h. Comparable but slightly more variable results were obtained using urine data corrected for voiding time (1.55 ± 0.67 h) and breath data corrected for mucous membrane desorption (1.40 ± 0.38 h) Methanol concentrations in blood lagged some 15-30 min behind the termination of exposure, and concentrations in urine were further delayed. (...)
Mots-clés Pascal : Méthanol, Exposition, Court terme, Homme, Inhalation, Marqueur biologique, Surveillance biologique, Liquide biologique, Urine, Sang, Air expiré, Accident travail, Médecine travail
Mots-clés Pascal anglais : Methanol, Exposure, Short term, Human, Inhalation, Biological marker, Biological monitoring, Biological fluid, Urine, Blood, Expired air, Occupational accident, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0437507
Code Inist : 002B03L06. Création : 25/01/1999.