N, N-dimethylformamide : influence of working conditions and skin penetration on the internal exposure of workers in synthetic textile production.
This study examined the external and internal exposure to the solvent N, N-dimethylformamide (DMF) of 126 workers from a factory producing synthetic fibers.
Air measurements were carried out using personal air samplers with diffusion tubes (Dräger, ORSA 5).
For the purpose of biological monitoring the levels of N-methylformamide (NM F) in urine were measured in preshift and postshift samples.
Determinations were carried out using gas chromatography.
Anamnestic data were collected with standardized questionnaires, including personal data, working history and current working conditions, and former and current illness with regard to the effects of DMF.
Skin diseases were documented by a dermatologist.
DMF concentrations measured in the air ranged between<0.1 and 37.9 ppm (median 1.2 ppm).
Concentrations of NMF varied from 0.05 to 22.0 mg/l (preshift values) and from 0.9 to 100.0 mg/l (postshift values).
The creatinine-related values (0.02-44.6 mg/g preshift ; 0.4-62.3 postshift) were subject to less variation and therefore represented the level of exposure better than the values related to volume.
Additional investigation of a subcollective (n=31) over a period of 4 days showed that NMF did not accumulate in the organism. (...)
Mots-clés Pascal : Formique acide diméthylamide, Solvant organique, Absorption, Peau, Voie externe, Industrie textile, Exposition professionnelle, Médecine travail, Condition travail, Surveillance biologique, Homme, Toxicocinétique, Pharmacocinétique, Vêtement protection
Mots-clés Pascal anglais : N,N-Dimethylformamide, Organic solvent, Absorption, Skin, Topical administration, Textile industry, Occupational exposure, Occupational medicine, Working condition, Biological monitoring, Human, Toxicokinetics, Pharmacokinetics, Safety clothing
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0437505
Code Inist : 002B03L04. Création : 25/01/1999.