Objectives This study assessed immunologic and early renal effects of chronic toluene exposure.
Methods In a longitudinal study of 92 printers and 74 referents, 145 subjects had pre-and poststudy samples of blood and urine taken for the following measurements :
immunoglobulin E (IgE), antiglomerular basement membrane (anti-GBM) and antilaminin (anti-LAM) antibodies in blood ;
creatinine and bêta2-microglobulin in blood and urine ;
N-acetyl-b-D-glucosaminidas (NAG) and alanine-aminopeptidase in urine.
Creatinine clearance was calculated according to the Cockroft-Gault formula.
Eight-hour personal air samples were collected twice to assess present exposure to toluene.
A job-exposure matrix was developed to estimate past cumulative exposure.
Information about potential confounders was recorded by questionnaire.
Multiple regression analysis was performed to study dose-effect relations adjusted for age and smoking.
Results No subject was positive for anti-GBM antibodies, and only 12 were positive for anti-LAM.
No relation was observed between the markers studied and present exposure to toluene except that creatinine clearance was higher among the exposed subjects than among the referents.
A dose-response relation was observed between cumulative toluene exposure and both IgE and NAG excretion.
No interaction was observed between hypertension and exposure, but the relationship with NAG did not persist when subjects with hypertension were excluded. (...)
Mots-clés Pascal : Toluène, Solvant organique, Exposition professionnelle, Rein pathologie, Homme, Immunopathologie, Imprimerie, Photogravure, Toxicité, Etude longitudinale, Marqueur biologique, Epidémiologie, Médecine travail, Appareil urinaire pathologie, France, Europe, Long terme
Mots-clés Pascal anglais : Toluene, Organic solvent, Occupational exposure, Kidney disease, Human, Immunopathology, Printing plant, Photoetching, Toxicity, Follow up study, Biological marker, Epidemiology, Occupational medicine, Urinary system disease, France, Europe, Long term
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0433865
Code Inist : 002B03L04. Création : 25/01/1999.