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  1. Serum ferritin : Screening test for colorectal cancer ? Editorial.

    Article - En anglais

    PURPOSE 

    There is increasing evidence that screening for colorectal cancer may save lives, and consequently, both professional and public interest in screening for colorectal cancer is increasing.

    As yet, however, there is no perfect screening test.

    Insidious blood loss is a common feature of colorectal cancer and may lead to a fall in serum ferritin before the patient becomes anemic.

    Measurement of serum ferritin, which is widely available and easily and inexpensively performed, has, therefore, been postulated as a potential screening test for colorectal cancer.

    METHOD 

    This study used samples of serum collected from 148 patients recruited to a screening study for colorectal cancer.

    All patients were thoroughly investigated by double-contrast barium enema and/or colonoscopy.

    Patients were selected randomly from each of three clinical diagnostic groups : 50 patients with proven colorectal cancer. 49 patients without colon disease, and patients with adenomas of the colon.

    Serum ferritin was assayed by immunoradiometry.

    The expected adult reference range is 25 to 350 mug/l, and results were reported without patient identification.

    RESULTS 

    There were no significant differences in serum ferritin levels among any of the three groups.

    CONCLUSION 

    Serum ferritin is unlikely to be of value as a screening test for colorectal cancer.

    Mots-clés Pascal : Carcinome, Côlon, Rectum, Dépistage, Examen laboratoire, Dosage, Ferritine, Sérum, Evaluation performance, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie

    Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Medical screening, Laboratory investigations, Assay, Ferritin, Serum, Performance evaluation, Human, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0433793

    Code Inist : 002B13C01. Création : 25/01/1999.