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  1. Audit of prehospital thrombolysis by general practitioners in peripheral practices in Grampian.

    Article - En anglais

    Background-In the Grampian region early anistreplase trial (GREAT), domiciliary thrombolysis by general practitioners was associated with a halving of one year mortality compared with hospital administration.

    However, after completion of the trial and publication of the results, the use of this treatment by general practitioners declined sharply.


    To increase the proportion of eligible patients receiving timely thrombolytic treatment from their general practitioners.

    Setting-Practices in Grampian located = 30 minutes'travelling time from Aberdeen Royal Infirmary, where patients with suspected acute myocardial infarction were referred after being seen by general practitioners.

    Audit standard-A call-to-needle time of 90 minutes, as proposed by the British Heart Foundation (BHF).

    Methods-Findings of this audit of prehospital management of acute myocardial infarction were periodically fed back to the participating doctors, when practice case reviews were also conducted.


    Of 414 administrations of thrombolytic treatment, 146 (35%) were given by general practitioners and 268 (65%) were deferred until after hospital admission.

    Median call-to-needle times were 45 (94% ¾ 90) and 145 (7% ¾ 90) minutes, respectively.

    Survival at one year was improved with prehospital compared with hospital thrombolysis (83% v 73% ; p<0.05).

    The proportion of patients receiving thrombolytic treatment from their general practitioners did not increase during the audit. (...)

    Mots-clés Pascal : Médecin généraliste, Fibrinolyse, Homme, Infarctus, Myocarde, Traitement, Fibrinolytique, Chimiothérapie, Exploration, Pratique professionnelle, Audit, Angleterre, Grande Bretagne, Royaume Uni, Europe, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie

    Mots-clés Pascal anglais : General practitioner, Fibrinolysis, Human, Infarct, Myocardium, Treatment, Fibrinolytic, Chemotherapy, Exploration, Professional practice, Audit, England, Great Britain, United Kingdom, Europe, Cardiovascular disease, Coronary heart disease, Myocardial disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0432509

    Code Inist : 002B02F03. Création : 25/01/1999.