A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation.
Background Recent case reports suggest that a combination of the appetite suppressants fenfluramine and phentermine is associated with an increased risk of cardiac-valve regurgitation.
There are also reports of valvular disorders in persons taking fenfluramine or dexfenfluramine alone, particularly for more than three months.
Methods We conducted a population-based follow-up study and a nested case-control analysis of 6532 subjects who received dexfenfluramine, 2371 who received fenfluramine, and 862 who received phentermine to assess the risk of a subsequent clinical diagnosis of a valvular disorder of uncertain origin.
For comparison, we identified a group of 9281 obese subjects who had not taken appetite suppressants who were matched to the treated subjects for age, sex, and weight.
All subjects were free of diagnosed cardiovascular disease at the start of follow-up.
The average duration of follow-up for all subjects was about four years.
Results There were 11 cases of newly diagnosed idiopathic valvular disorders, 5 after the use of dexfenfluramine and 6 after the use of fenfluramine.
There were six cases of aortic regurgitation, two cases of mitral regurgitation, and three cases of combined aortic and mitral regurgitation.
There were no cases of idiopathic cardiac-valve abnormalities among the subjects who had not taken appetite suppressants or among those who took only phentermine. (...)
Mots-clés Pascal : Régurgitation, Valvule mitrale, Facteur risque, Fenfluramine, Chimiothérapie, Association, Etude longitudinale, Etude cas témoin, Evaluation, Homme, Amphétamine dérivé, Appareil circulatoire pathologie, Cardiopathie valvulaire, Anorexigène, Agoniste, Récepteur sérotoninergique
Mots-clés Pascal anglais : Regurgitation, Mitral valve, Risk factor, Fenfluramine, Chemotherapy, Association, Follow up study, Case control study, Evaluation, Human, Amphetamine derivatives, Cardiovascular disease, Cardiac valvular disease, Anorectic, Agonist, Serotonine receptor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0432448
Code Inist : 002B02U03. Création : 25/01/1999.