Objectives-To better understand the relations between occupational exposure, blood antioxidant enzyme activities, total plasma antioxidant concentration, and the severity of coal workers'pneumoconiosis (CWP).
Methods-Blood samples were obtained from miners without CWP exposed to low dust concentrations for =4 years at the time of the study (n=105), or exposed to high dust concentrations for =14 years at the time of the study (n=58), and from retired miners with CWP (n=19).
Miners without CWP were classified into three subgroups according to their estimated cumulative exposure to dust.
Chest x ray films were obtained for each miner.
Miners were classified in five subgroups according to their International Labour Organisation (ILO) profusion grades.
Univariate tests were completed by multiple linear regression analyses.
The estimated cumulative exposure to dust was strongly positively related to erythrocyte catalase activity and strongly negatively related to Cu+/Zn+SOD activity only in miners exposed to high dust concentrations for =14 years at the time of the study (F tests p=0.006 and p=0.004 respectively).
Moreover, catalase activity was strongly related to the severity of CWP expressed as five subgroups of ILO profusion grades (F test p=0.003) ; the greatest difference in the mean values was found between the group of 1/1 to 112 ILO profusion grades and the group of 211 to 313 ILO profusion grades. (...)
Mots-clés Pascal : Mine, Industrie extractive, Charbon, Homme, Pneumoconiose, Exposition professionnelle, Médecine travail, Toxicité, Stress oxydatif, Marqueur biologique, Catalase, Peroxidases, Oxidoreductases, Enzyme, Superoxide dismutase, Erythrocyte, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Mine, Mining industry, Coal, Human, Pneumoconiosis, Occupational exposure, Occupational medicine, Toxicity, Oxidative stress, Biological marker, Catalase, Peroxidases, Oxidoreductases, Enzyme, Superoxide dismutase, Red blood cell, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0431791
Code Inist : 002B03L03. Création : 25/01/1999.