logo BDSP

Base documentaire

  1. Has the impact of Helicobacter pylori therapy on ulcer recurrence in the united states been overstated ? A meta-analysis of rigorously designed trials.

    Article - En anglais


    The aim of this study was to assess the effect of H. pylori eradication on ulcer recurrence in North American duodenal ulcer patients by examining only treatment studies that met rigorous methodologic criteria.


    Data sources were computerized bibliographic searches from 1983, review of reference lists, communication with companies that manufacture medications used for H. pylori therapy in the U.S., and H. pylori investigators, review of open presentations to the Food and Drug Administration, and review of abstracts from annual scientific meetings.

    Criteria for study inclusion were double blind, randomized North American trials of H. pylori therapy for duodenal ulcer, scheduled endoscopic follow-up exams for =6 months, and H. pylori cure documented =4 wk after completion of therapy by at least two endoscopic biopsy tests.

    Seven relevant trials were identified.

    Data were abstracted independently and disagreement was resolved by consensus.

    We obtained missing data and identified erroneous assessments through contact with an author or sponsor of all studies.


    The common odds ratio for ulcer recurrence was 0.20 (95% CI, 0.13-0.31) and 2.8 patients would need to be successfully treated to prevent one ulcer recurrence at 6 months.

    The pooled ulcer recurrence rate at 6 months in patients with H. pylon eradication was 20%. Conclusion : Results of North American studies of highest methodological quality confirm that H. (...)

    Mots-clés Pascal : Ulcère, Duodénum, Association morbide, Gastrite, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Effet biologique, Eradication, Chimiothérapie, Incidence, Récidive, Métaanalyse, Homme, Appareil digestif pathologie, Intestin pathologie, Estomac pathologie

    Mots-clés Pascal anglais : Ulcer, Duodenum, Concomitant disease, Gastritis, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Biological effect, Eradication, Chemotherapy, Incidence, Relapse, Metaanalysis, Human, Digestive diseases, Intestinal disease, Gastric disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0431435

    Code Inist : 002B02S02. Création : 25/01/1999.