To examine the association of peripheral blood mononuclear cell (PBMC) derived interleukin 1bêta (IL-1bêta), IL-I receptor antagonist (IL-1Ra), tumor necrosis factor alpha (TNF-alpha), and radiographic osteoarthritis (OA) in the elderly.
A total of 703 subjects (436 women, 267 men, mean age 78.5 ±4.5 yrs) had both knee and hand radiographs. and cytokines were measured during the 22nd biennial examination of the Framingham Cohort.
PBMC derived IL-1bêta, IL-1Ra, and TNF-alpha production was assessed using a non-cross reacting polyclonal radioimmunoassay.
Knee OA was defined as a score of>2 using a modified Kellgren and Lawrence scale.
The presence of osteophytes and joint space narrowing were scored separately on a 0-3 scale, in which disease was defined a priori as a score>0 for each feature.
Sex-specific odds ratios were calculated for knee OA after adjusting for weight, history of knee injury, and use of estrogen and nonsteroidal antiinflammatory drugs.
No uniform associations were found for IL-1bêta or IL-1Ra in men, or for TNF-alpha production and radiographic OA in either sex.
We found possible associations for the highest levels of IL-1bêta production and the presence of knee osteophytes [OR=2.0 (1.2-3.5) ] and joint space narrowing [OR=1.7 (1.1-2.8) ] in women.
Out data suggested a possible protective effect for IL-1Ra production and hand OA in women [OR=0.6 (0.4-1.0) ]. Conclusion. (...)
Mots-clés Pascal : Arthrose, Vieillard, Homme, Pathogénie, Facteur nécrose tumorale alpha, Interleukine 1bêta, Récepteur biologique, Radiographie, Exploration, Méthode radioimmunologique, Epidémiologie, Facteur risque, Mononucléaire, Sang, Inflammation, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative, Cytokine, Radiodiagnostic, IL-1Ra
Mots-clés Pascal anglais : Osteoarthritis, Elderly, Human, Pathogenesis, Tumor necrosis factor alpha, Interleukin 1bêta, Biological receptor, Radiography, Exploration, Radioimmunoassay, Epidemiology, Risk factor, Mononuclear cell, Blood, Inflammation, Diseases of the osteoarticular system, Arthropathy, Degenerative disease, Cytokine, Radiodiagnosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0430988
Code Inist : 002B15E. Création : 25/01/1999.