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  1. Use of antimicrobials and resistance in bacteria isolated from blood cultures in a Danish county from 1992 to 1995.

    Article - En anglais

    Objective 

    To compare the usage of antibiotics and the resistance frequencies in blood culture isolates in a low-consumption area (Roskilde County, Denmark) in the period 1992-1995.

    Methods 

    Data from relevant institutions were collected and processed.

    Results 

    In 1995 the total use of antibiotics was 16.7 defined daily doses (DDD) 1000 inhabitants per day, 95% of this being in the primary healthcare sector.

    In primary health care, only 0.1% of the total use was cephalosporins, 2% fluoroquinolones, 11% tetracyclines, 29% macrolides and 59% penicillins.

    In hospitals, 7% were cephalosporins, 3% fluoroquinolones, 0.7% tetracyclines, 10% macrolides and 59% penicillins.

    The total use in hospitals was 37 DDD/100 bed-days.

    Resistance frequencies did not change in the period.

    Resistance against penicillin and erythromycin in Streptococcus pneumoniae was 0.6% and 1.8% respectively.

    Resistance against methicillin in Staphylococcus aureus was 0.8%, and resistance against ampicillin, cefuroxime, gentamicin and fluoroquinolones in Escherichia coli was 31%, 0.5%, 0.8% and 0.8%, respectively.

    The frequencies of multiresistant coagulase-negative staphylococci correlated with the use of antibiotics in different ward groups according to the use of antibiotics.

    Conclusions 

    In this 4-year study period, the changes in the use of antibiotics were negligible and were not reflected as alterations in the resistance frequencies in single species. (...)

    Mots-clés Pascal : Isolat clinique, Hémoculture, Résistance, Antibactérien, Antibiotique, Utilisation, Fréquence, Surveillance sanitaire, Microorganisme, Sang, Epidémiologie, Suède, Europe

    Mots-clés Pascal anglais : Clinical isolate, Blood culture, Resistance, Antibacterial agent, Antibiotic, Use, Frequency, Sanitary surveillance, Microorganism, Blood, Epidemiology, Sweden, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0430260

    Code Inist : 002B02S02. Création : 25/01/1999.