To compare the usage of antibiotics and the resistance frequencies in blood culture isolates in a low-consumption area (Roskilde County, Denmark) in the period 1992-1995.
Data from relevant institutions were collected and processed.
In 1995 the total use of antibiotics was 16.7 defined daily doses (DDD) 1000 inhabitants per day, 95% of this being in the primary healthcare sector.
In primary health care, only 0.1% of the total use was cephalosporins, 2% fluoroquinolones, 11% tetracyclines, 29% macrolides and 59% penicillins.
In hospitals, 7% were cephalosporins, 3% fluoroquinolones, 0.7% tetracyclines, 10% macrolides and 59% penicillins.
The total use in hospitals was 37 DDD/100 bed-days.
Resistance frequencies did not change in the period.
Resistance against penicillin and erythromycin in Streptococcus pneumoniae was 0.6% and 1.8% respectively.
Resistance against methicillin in Staphylococcus aureus was 0.8%, and resistance against ampicillin, cefuroxime, gentamicin and fluoroquinolones in Escherichia coli was 31%, 0.5%, 0.8% and 0.8%, respectively.
The frequencies of multiresistant coagulase-negative staphylococci correlated with the use of antibiotics in different ward groups according to the use of antibiotics.
In this 4-year study period, the changes in the use of antibiotics were negligible and were not reflected as alterations in the resistance frequencies in single species. (...)
Mots-clés Pascal : Isolat clinique, Hémoculture, Résistance, Antibactérien, Antibiotique, Utilisation, Fréquence, Surveillance sanitaire, Microorganisme, Sang, Epidémiologie, Suède, Europe
Mots-clés Pascal anglais : Clinical isolate, Blood culture, Resistance, Antibacterial agent, Antibiotic, Use, Frequency, Sanitary surveillance, Microorganism, Blood, Epidemiology, Sweden, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0430260
Code Inist : 002B02S02. Création : 25/01/1999.