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  1. How reliable are human hair reference intervals for trace elements ?

    Article - En anglais

    Inductively coupled plasma mass spectrometry (ICP-MS) was used for the determination of major and trace element concentrations in scalp hair samples from a population group (N=1091) of Rio de Janeiro city.

    From these results, preliminary'normal'or reference intervals were calculated which are for several trace elements (e.g. B, V, Co, Ge, Mo, Au, As, Se, Sb, Th), but also for some minor elements (e.g. Ca, Mg) in disaccord with data published by five clinical laboratories which used inductively coupled plasma atomic emission spectrometry (ICP-AES).

    The limitations of ICP-AES in routine hair analysis is shown by comparison of detection limits for both methods and by results from two laboratory intercomparison exercises.

    It is evident from these data that published reference intervals have to be used with extreme caution and that their urgent revision, based on reliable data produced by the ICP-MS technique, is of extreme importance.

    Mots-clés Pascal : Pollution air, Méthode analyse, Analyse chimique, Analyse trace, Métal lourd, Cheveu, Homme, Etude comparative, Spectrométrie masse, Plasma couplé inductivement, Limite détection, Surveillance biologique

    Mots-clés Pascal anglais : Air pollution, Analysis method, Chemical analysis, Trace analysis, Heavy metal, Hair (head), Human, Comparative study, Mass spectrometry, Inductively coupled plasma, Detection limit, Biological monitoring

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0429960

    Code Inist : 001D16C03. Création : 25/01/1999.