Malignant lymphoma in Thailand : Changes in the frequency of malignant lymphoma determined from a histopathologic and immunophenotypic analysis of 425 cases at Siriraj hospital.
Analysis of malignant lymphoma in a single institution at different periods of time can determine the changing status of the disease in the region.
To compare with the large series of 1095 lymphoma cases reported between 1957-1971 at Siriraj Hospital, the largest hospital in Thailand, a similar study was performed through histopathologic evaluation of 425 lymphoma cases diagnosed consecutively at the same institution between August 1993 and October 1995.
Phenotypic analysis was performed by paraffin section-immunoperoxidase studies.
A striking increase in lymphoma cases was noted from 73 cases/year in the first series to 189 cases/year in the second series (an increase of 158.9%). Lymphoma occurred in all age groups, with a peak incidence at the seventh decade of life.
The male to female ratio decreased from 2 : 1 in 1957-1971 to 1.3 : 1 in the more recent series.
The incidence of Hodgkin's disease (HD) was found to have decreased from 28.9% to 8.5%. There were 36 cases (8.5%) of HD and 389 cases (91.5%) of non-Hodgkin's lymphoma (NHL) reported in the second series.
The subtypes of HD included 16 cases of mixed cellularity, 13 cases of nodular sclerosis, 6 cases of lymphocyte depletion, and 1 case of lymphocyte predominance.
According to the Working Formulation, the 389 NHL cases included low grade (14.1%), intermediate grade (57.3%), high grade (11.3%), and miscellaneous groups (17.2%). They were classified as small lymphocytic (9. (...)
Mots-clés Pascal : Hodgkin maladie, Lymphome non hodgkinien, Incidence, Type histologique, Grade histologique, Histopathologie, Phénotype, Exploration immunologique, Epidémiologie, Thaïlande, Asie, Homme, Hémopathie maligne, Lymphoprolifératif syndrome, Lymphome, Anatomopathologie
Mots-clés Pascal anglais : Hodgkin disease, Non Hodgkin lymphoma, Incidence, Histological type, Histological grading, Histopathology, Phenotype, Immunological investigation, Epidemiology, Thailand, Asia, Human, Malignant hemopathy, Lymphoproliferative syndrome, Lymphoma, Pathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0429639
Code Inist : 002B19B. Création : 25/01/1999.