Mortality and cancer incidence among Swedish paint industry workers with long-term exposure to organic solvents.
Objectives The aim of this update on a cohort of male paint industry workers was to determine whether an excess of mortality and incidence of lymphatic and hematopoietic tumors, particularly multiple myeloma, still exists, and, if so, to determine if it is due to exposures occurring before the mid-1950s, when benzene disappeared as a solvent in the Swedish paint industry.
Methods The cohort of 41 1 men who had worked in the Swedish paint industry and had been exposed to organic solvents for at least 5 years during 1955-1975 was followed from 1961 to 1994 for causes of death in the mortality register and from 1961 to 1992 for cases of cancer in the Swedish cancer register.
Results The number of paint industry workers who had died, plus the number of deaths in the major disease groups and the number of cancers reported to the cancer registry, was close to the expected.
The incidence of prostatic cancer increased somewhat [standardized incidence ratio (SIR) 1.5,95% confidence interval (95% CI) 1.0-2.2]. Among the workers first employed in 1956 or earlier, there was an increase in both the incidence and mortality from all lymphatic and hematopoietic tumors [SIR 2.3,95% CI 1.0-2.2 ; standardized mortality ratio (SMR) 2.0,95% CI0.7-4.4]. The excess was particularly marked for multiple myeloma (SIR 3.8,95% CI0.8-11 ; SMR 4.4,95% CI0.9-13). (...)
Mots-clés Pascal : Myélome, Lymphome non hodgkinien, Mortalité, Industrie, Peinture, Solvant organique, Exposition professionnelle, Toxicité, Homme, Epidémiologie, Médecine travail, Suède, Europe, Etude longitudinale, Hémopathie maligne, Lymphoprolifératif syndrome, Immunopathologie, Immunoglobulinopathie
Mots-clés Pascal anglais : Myeloma, Non Hodgkin lymphoma, Mortality, Industry, Paint, Organic solvent, Occupational exposure, Toxicity, Human, Epidemiology, Occupational medicine, Sweden, Europe, Follow up study, Malignant hemopathy, Lymphoproliferative syndrome, Immunopathology, Immunoglobulinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0429084
Code Inist : 002B19B. Création : 25/01/1999.