Meta-analyses of non-Hodgkin's lymphoma and farming.
Objectives This study examined the association between non-Hodgkin's lymphoma (NHL) and farming.
Methods A series of meta-analyses of peer-reviewed studies was performed using 36 studies published between 1982 and 1997.
Prior to the meta-analyses. all the studies were reviewed and evaluated for heterogeneity and publication bias.
Combined relative risks (RR) were calculated using the random effect model.
Results The combined RR was 1.10 [95% confidence interval (95% CI) 1.03-1.19] for all the studies and 0.93 (95% Cl 0.82-1.06) for studies involving female farmers.
Significant heterogeneity was detected for study design and country of study among the studies.
Significantly elevated RR values were obtained for case-referent studies (combined RR 1.19,95% CI 1.06-1.33) and for studies conducted on farmers residing in the United States (combined RR 1.26,95% CI 1.15-1.37).
These findings were not influenced by a publication bias.
Conclusions The findings suggest that male farmers residing in the United States have a slightly elevated risk of contracting NHL.
Commonly experienced exposures that might contribute to the occurrence of NHL in this group include infectious microorganisms, herbicides, and insecticides.
Mots-clés Pascal : Lymphome non hodgkinien, Exposition professionnelle, Agriculture, Homme, Métaanalyse, Revue bibliographique, Sexe, Etats Unis, Amérique du Nord, Amérique, Facteur risque, Médecine travail, Article synthèse, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Occupational exposure, Agriculture, Human, Metaanalysis, Bibliographic review, Sex, United States, North America, America, Risk factor, Occupational medicine, Review, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0429081
Code Inist : 002B19B. Création : 25/01/1999.