To evaluate the possible association between vasectomy and prostate cancer.
Systematic review of the literature.
Fourteen original studies published between January 1985 and Decemher 1996 that addressed the association between vasectomy and prostate cancer.
The strength of the association was estimated with the use of a meta-analysis (DerSimonian and Laird method).
A sensitivity analysis was conducted to assess the impact of different sources of heterogeneity.
Fourteen original papers were reviewed (5 cohort and 9 case-control studies).
Relative risks ranged between 0.44 (95% confidence interval [CI]=0.1-4.0) and 6.70 (95% Cl=2.1-21.6).
The overall relative risk (DerSimonian and Laird estimate) was 1.23 (95% Cl=1.01-1.49).
The sensitivity analysis showed that this measure was very sensitive to the study base, the type of design used, and the possibility of bias.
Further. the funnel plot demonstrated the probable existence of publication bias.
No causal association was found between vasectomy and prostate cancer.
Individuals who have undergone vasectomy are not at high risk for the development of prostate cancer.
Mots-clés Pascal : Epidémiologie, Revue bibliographique, Vasectomie, Facteur risque, Complication, Tumeur maligne, Prostate, Chirurgie, Voie génitale mâle, Canal déférent, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie, Homme, Mâle, Article synthèse
Mots-clés Pascal anglais : Epidemiology, Bibliographic review, Vasectomy, Risk factor, Complication, Malignant tumor, Prostate, Surgery, Male genital duct, Vas deferens, Male genital diseases, Urinary system disease, Prostate disease, Human, Male, Review
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0427371
Code Inist : 002B25K. Création : 25/01/1999.