Although during pregnancy there is a better correlation between maternal serum cotinine concentration and adverse outcome than between self-reported smoking and such an outcome, few studies of pregnancy have measured cotinine concentration to determine how much a woman smokes.
This study assessed the accuracy of self-reported smoking during pregnancy by performing serum cotinine assays on 448 women registered in the Collaborative Perinatal Project (1959-1966).
Based on the assumption that a serum cotinine concentration of>10 ng/ml represented active smoking, 94.9% of women who denied smoking and 87.0% of women who stated that they smoked (kappa=0.83) reported their status accurately.
Among smokers, the correlation coefficient between cotinine concentration and number of cigarettes smoked per day was 0.44.
Serum cotinine concentration correlated more strongly than self-reported smoking with infant birth weight (r=0.246 vs. 0.200).
In conclusion, this study showed that pregnant women accurately reported whether they smoked, but cotinine concentration was a better measure than self-report of the actual tobacco dose received.
Mots-clés Pascal : Tabagisme, Gestation, Nicotine, Plasma sanguin, Taux, Marqueur biologique, Autoévaluation, Consommation, Tabac, Corrélation, Etude comparative, Homme, Epidémiologie, Etude cohorte, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Tobacco smoking, Pregnancy, Nicotine, Blood plasma, Rate, Biological marker, Self evaluation, Consumption, Tobacco, Correlation, Comparative study, Human, Epidemiology, Cohort study, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0426225
Code Inist : 002B18C05C. Création : 25/01/1999.