Associations between antioxidants and zinc and the 5-year incidence of early, age-related maculopathy (ARM) were investigated in a population-based cohort of middle-aged and older adults participating in the Beaver Dam Eye Study in Beaver Dam, Wisconsin.
A food-frequency questionnaire was administered at baseline (1988-1990) to collect dietary information for that time period and a period of time 10 years earlier (1978-1980) from a 50 percent random sample of persons participating in this study.
The incidence of the specific lesions of larger drusen (>125 mu) and pigmentary abnormalities and the incidence of any ARM were assessed by masked grading of stereoscopic color fundus photographs in 1,709 persons who participated in 5-year follow-up eye examinations.
Significant, but modest, inverse associations (p<0.05) were observed between intakes of pro-vitamin A carotenoids and dietary vitamin E and the incidence of large drusen and between zinc and the incidence of pigmentary abnormalities.
No significant inverse associations were found between antioxidant or zinc intake and the incidence of overall early ARM.
If ARM, which is characterized by a broad spectrum of lesions, involves a number of different underlying pathophysiologic processes, then associations between specific antioxidants and the incidence of distinct macular lesions may be biologically important. (...)
Mots-clés Pascal : Maculopathie, Antioxydant, Zinc, Régime alimentaire, Age, Epidémiologie, Facteur risque, Incidence, Homme, Toxicité, Etude cohorte, Etats Unis, Amérique du Nord, Amérique, Oeil pathologie, Alimentation
Mots-clés Pascal anglais : Maculopathy, Antioxidant, Zinc, Diet, Age, Epidemiology, Risk factor, Incidence, Human, Toxicity, Cohort study, United States, North America, America, Eye disease, Feeding
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0426029
Code Inist : 002B09N. Création : 25/01/1999.