Data from a population-based case-control study of Wisconsin women were used to evaluate the relation of diabetes to the risk of endometrial cancer on the basis of body mass index (BMI).
Cases (n=723) were identified from a statewide tumor registry ; controls (n=2,291) were selected randomly from population lists.
Diabetes status, weight, height, and other factors were ascertained by telephone interview.
Subjects were categorized as not overweight (BMI,<29.1), overweight (BMI, 29.1-31.9), or obese (BMI,>31.9) according to the BMI distribution of middle-aged white women in the Second National Health and Nutrition Examination Survey.
Joint associations between diabetes status, BMI, and endometrial cancer were evaluated using unconditional logistic regression models that controlled for age, parity, use of hormone replacement therapy, education, and smoking.
Compared with persons without diabetes, those with diabetes had an adjusted odds ratio of 1.86 (95% confidence interval (Cl) 1.37-2.52) for endometrial cancer.
This association was modified by BMI (p interaction=0.04).
Compared with nonoverweight nondiabetic subjects, nonoverweight and overweight women who reported diabetes had nonsignificant elevated risks of endometrial cancer (nonoverweight, odds ratio (OR)=1.10, Cl 0.66-1.86 ; overweight, OR=1.58, Cl 0.81-3.05).
In contrast, elevated risk estimates were observed for obese diabetic women (OR=2.95, Cl 1.60-5.46). (...)
Mots-clés Pascal : Tumeur maligne, Endomètre, Diabète, Indice masse corporelle, Taille corporelle, Epidémiologie, Facteur risque, Homme, Etats Unis, Amérique du Nord, Amérique, Appareil génital femelle pathologie, Utérus pathologie, Endocrinopathie, Biométrie corporelle
Mots-clés Pascal anglais : Malignant tumor, Endometrium, Diabetes mellitus, Body mass index, Body size, Epidemiology, Risk factor, Human, United States, North America, America, Female genital diseases, Uterine diseases, Endocrinopathy, Corporal biometry
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0425559
Code Inist : 002B30A01A2. Création : 25/01/1999.