An industry-wide mortality study on the association between lung cancer and occupational exposure to cobalt and tungsten carbide was carried out in the French hard-metal industry.
This case-control study was nested in the historical cohort of workers ever employed in this industry's 10 facilities, most of which are located in eastern France.
Workers were followed up from 1968 to 1991.
Occupational exposure was assessed using a job-exposure matrix that provided semiquantitative scores for 320 job periods.
These scores were significantly correlated with the levels of cobalt measured in 744 historical air samples.
In this cohort, which comprised 5,777 males and 1,682 females, the death rate from lung cancer was significant (63 deaths, standardized mortality ratio=1.30,95% confidence interval (Cl) 1.00-1.66) when compared with national death rates.
Sixty-one cases and 180 controls were included in the study.
When the exposures during the last 10 years were ignored, a twofold lung cancer risk was observed among workers simultaneously exposed to cobalt and tungsten carbide (odds ratio (OR)=1.93,95% Cl 1.03-3.62) adjusted for other cobalt exposure (OR=2.21,95% Cl 0.99-4.90).
The odds ratios increased with cumulative exposure (first quartile, OR=1.00 ; second quartile, OR=2.64 ; third quartile, OR=2.59 ; fourth quartile, OR=4.13) and, to a lesser degree, with duration of exposure (one decade, OR=1.00 ; two decades, OR=1.61 ; three decades, OR=2.77 ; four decades, OR=2.03). (...)
Mots-clés Pascal : Tumeur maligne, Poumon, Mortalité, Cobalt, Tungstène composé, Exposition professionnelle, Activité professionnelle, Industrie, Epidémiologie, Facteur risque, Homme, France, Europe, Etude cas témoin, Médecine travail, Appareil respiratoire pathologie, Poumon pathologie, Métal lourd, Toxicité
Mots-clés Pascal anglais : Malignant tumor, Lung, Mortality, Cobalt, Tungsten compound, Occupational exposure, Professional activity, Industry, Epidemiology, Risk factor, Human, France, Europe, Case control study, Occupational medicine, Respiratory disease, Lung disease, Heavy metal, Toxicity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0424396
Code Inist : 002B03L05. Création : 25/01/1999.