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  1. Susceptibility of European respiratory tract isolates to trovafloxacin, ciprofloxacin, clarithromycin, azithromycin and ampicillin : Trovafloxacin : In vitro activity, pharmacokinetics, and clinical experience.

    Article - En anglais

    As part of the Artemis project, 11 500 isolates (3000 from patients with respiratory tract infections) were collected throughout six European countries between 1994 and 1996.

    Twenty-seven hospitals or laboratories participated in this first phase of the study.

    The activities of three classes of antimicrobial agents (fluor-oquinolones. bêta-lactam agents. macrolides) are presented for the six most frequently isolated pathogens (Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis.

    Pseudomonas aeruginosa, Klebsiella pneumoniae).

    Overall, trovafloxacin and ciprofloxacin activities were similar for Haemophilus influenzae.

    Moraxella catarrhalis and Klebsiella pneumoniae isolates.

    Of the Strepto-coccus pneumoniae isolates, 6% were resistant to penicillin.

    Trovafloxacin had the highest activity against the Streptococcus pneumoniae isolates. with a minimum inhibitory concentration of 0.25 mg/l for 90% of isolates (MIC90) ; all strains tested were susceptible to trovafloxacin.

    The MIC90 of ciprofloxacin for Streptococcus pneumoniae was 3 mg/l. and overall 52% of the strains were susceptible ; 9% were resistant.

    Azithromycin and clarithromycin exhibited similar activity against all collected pathogens, except Haemophilus influenzae, All strains of Haemophilus influenzae were susceptible to azithromycin compared with 79% for clarithromycin. with respective MIC90s of 2 and 16 mg/l. (...)

    Mots-clés Pascal : Clarithromycine, Antibactérien, Antibiotique, Trovafloxacine, Spectre activité, Souche pathogène, Azithromycine, Voie respiratoire, Activité biologique, Ampicilline, Sensibilité résistance, Epidémiologie, Ciprofloxacine, Streptococcus pneumoniae, Streptococcaceae, Micrococcales, Bactérie, Staphylococcus aureus, Micrococcaceae, Pseudomonas aeruginosa, Pseudomonadaceae, Pseudomonadales, Branhamella catarrhalis, Neisseriaceae, Klebsiella pneumoniae, Enterobacteriaceae, Haemophilus influenzae, Pasteurellaceae, Europe, Test sensibilité médicamenteuse, Macrolide, Pénicilline dérivé, Fluoroquinolone dérivé, Quinolone dérivé, Surveillance sanitaire

    Mots-clés Pascal anglais : Clarithromycin, Antibacterial agent, Antibiotic, Trovafloxacin, Activity spectrum, Pathogen strain, Azithromycin, Respiratory tract, Biological activity, Ampicillin, Sensitivity resistance, Epidemiology, Ciprofloxacin, Streptococcus pneumoniae, Streptococcaceae, Micrococcales, Bacteria, Staphylococcus aureus, Micrococcaceae, Pseudomonas aeruginosa, Pseudomonadaceae, Pseudomonadales, Branhamella catarrhalis, Neisseriaceae, Klebsiella pneumoniae, Enterobacteriaceae, Haemophilus influenzae, Pasteurellaceae, Europe, Drug susceptibility test, Macrolide, Penicillin derivatives, Fluoroquinolone derivatives, Quinolone derivatives, Sanitary surveillance

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0423267

    Code Inist : 002B02S02. Création : 25/01/1999.