This analysis evaluated the extent to which infections with selected blood-borne viruses, specifically infection with hepatitis B virus, hepatitis C virus, and/or the human immunodeficiency virus (HIV), continue to contribute to the morbidity of persons with hemophilia.
The Georgia Hemophilia Surveillance System collected information on 336 state residents with hemophilia A or B who were followed by a physician in 1994.
Data abstracted from medical records included information on demographics, sources of hemophilia care, clinical characteristics, joint range of motion measurements, hospitalization, and results of laboratory testing for hepatitis B, hepatitis C, and the human immunodeficiency virus.
Prevalence of infection with one or more of these viruses was determined, and relationships with disease severity, bleeding frequency, and amount of clotting factor prescribed were explored.
No child under the age of ten was positive for the human Immunodeficiency virus ; hepatitis infection was also uncommon in this age group, in contrast to the very high frequency of such infections among older subjects.
There was a strong association between HIV positive status and infection with one of the hepatitis viruses.
The likelihood of all types of viral infection increased with frequency of bleeding and with amount of clotting factor received.
Efforts to prevent transmission of lipid-enveloped viruses via clotting factor have been extremely effective. (...)
Mots-clés Pascal : Hémophilie, Transfusion, Facteur coagulation, Constituant sang, Traitement, Complication, Hépatite virale, Virose, Infection, SIDA, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Epidémiologie, Géorgie, Etats Unis, Amérique du Nord, Amérique, Homme, Hémopathie, Coagulopathie, Maladie héréditaire, Immunodéficit, Immunopathologie, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Hemophilia, Transfusion, Coagulation factor, Blood product, Treatment, Complication, Viral hepatitis, Viral disease, Infection, AIDS, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Epidemiology, Georgia, United States, North America, America, Human, Hemopathy, Coagulopathy, Genetic disease, Immune deficiency, Immunopathology, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0423220
Code Inist : 002B27D02. Création : 25/01/1999.