Which contacts of patients with meningococcal disease carry the pathogenic strain of Neisseria meningitidis ? A population based study.
To determine the prevalence of the pathogenic strain of Neisseria meningitidis in contacts of patients with meningococcal disease, and to determine which contact groups are likely to be carriers and warrant chemoprophylaxis.
Population based study.
Norwegian county of Telemark.
1535 primary contacts of 48 patients with meningococcal disease, and 78 secondary contacts.
Carriers of the pathogenic strain were treated with rifampicin.
All household members and kissing contacts under 15 years of age were treated with oral penicillin.
Contacts were taught to recognise the symptoms of meningococcal disease.
In 27 of 48 cases investigated, contacts carrying the pathogenic strain of N meningitidis were found.
A total of 42 such contacts were identified.
Contacts were stratified into three classes according to the assumed closeness of contact with patients.
In class 1 (household members and kissing contacts) the prevalence of the pathogenic strain was 12.4% (95% confidence interval 5.5% to 19.3%). In classes 2 and 3 the prevalence was 1.9% (0.9% to 3.4%) and 1.6% (0.14% to 3.1%). Conclusions : There is a high rate of carriage of the pathogenic strain of N meningitidis in patients'household members and kissing contacts, and this supports the practice of giving chemoprophylaxis to these contacts.
The prevalence of carriage among other contacts is 2-3 times that found in the general population (0. (...)
Mots-clés Pascal : Neisseria meningitidis, Neisseriaceae, Micrococcales, Bactérie, Méningococcie, Bactériose, Infection, Homme, Prévalence, Interaction contact, Chimiothérapie, Rifampicine, Traitement, Porteur, Souche pathogène, Pénicilline, Transmission homme homme, Prévention, Efficacité traitement, Nasopharynx, Dépistage, Antibiotique, Antibactérien
Mots-clés Pascal anglais : Neisseria meningitidis, Neisseriaceae, Micrococcales, Bacteria, Meningococcal disease, Bacteriosis, Infection, Human, Prevalence, Contact interaction, Chemotherapy, Rifampicin, Treatment, Carrier, Pathogen strain, Penicillin, Transmission from man to man, Prevention, Treatment efficiency, Nasopharynx, Medical screening, Antibiotic, Antibacterial agent
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0420658
Code Inist : 002B05B02I. Création : 25/01/1999.