Clinicians at the Fox Chase Cancer Center (FCCC) base prostate carcinoma treatment decisions regarding need to treat, field size, total dose, and adjuvant hormonal therapy on known prognostic factors including clinical stage, Gleason score (GS), perineural invasion (PNI), and pretreatment prostate specific antigen levels.
The pathology of every patient is reviewed at FCCC to confirm a diagnosis of malignancy.
The objective of this study was to define differences between pathologic reviews and their impact on treatment between outside institutions and FCCC.
The authors reviewed 538 pathology reports of prostate biopsies performed at both outside pathology departments and FCCC on patients evaluated between January 1993 and December 1996.
The outside pathology reviews represented 107 community hospitals, academic institutions, and private pathology laboratories.
Patients who had received hormonal therapy, cryosurgery, or radical prostatectomy prior to prostate biopsy were excluded from analysis.
Final FCCC pathology determinations were compared with pathology reports from outside institutions.
Reports then were analyzed to determine whether differences in interpretation would have resulted in different treatment strategies.
Differences in percentages according to institutional type were evaluated using the chi-square statistic.
The cost was assessed and cost per change in treatment estimated.
Mots-clés Pascal : Carcinome, Prostate, Grade histologique, Histopathologie, Examen laboratoire, Etude comparative, Analyse coût, Economie santé, Traitement, Echelle évaluation, Homme, Tumeur maligne, Prostate pathologie, Appareil urinaire pathologie, Appareil génital mâle pathologie, Anatomopathologie, Echelle Gleason
Mots-clés Pascal anglais : Carcinoma, Prostate, Histological grading, Histopathology, Laboratory investigations, Comparative study, Cost analysis, Health economy, Treatment, Evaluation scale, Human, Malignant tumor, Prostate disease, Urinary system disease, Male genital diseases, Pathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0416441
Code Inist : 002B14D02. Création : 25/01/1999.